Results 111 to 120 of about 12,719,567 (285)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Retracted: Research on Computer-Aided Product Design Technology. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Encoding orbital angular momentum of light in space with optical catastrophes

Nature Communications
Light beams carrying orbital angular momentum (OAM) possess an unbounded set of orthogonal modes, offering significant potential for optical communication and security.
Xiaoyan Zhou, John You En Chan, Chia-Te Chang, Zhenchao Liu, Hao Wang, Andrew Forbes, Cheng-Wei Qiu, Hongtao Wang, Joel K. W. Yang   +8 more
doaj   +1 more source

Enhancing Robot Inclusivity in the Built Environment: A Digital Twin-Assisted Assessment of Design Guideline Compliance

Buildings
Developing guidelines for designing robot-inclusive spaces has been challenging and resource-intensive, primarily relying on physical experiments and observations of robot interactions within the built environment.
Anilkumar Ezhilarasu, J.J. J. Pey, M. A. Viraj J. Muthugala, Michael Budig, Mohan Rajesh Elara   +4 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

A deep dive into addressing obsolescence in product design: A review. [PDF]

Heliyon, 2023
Sierra-Fontalvo L, Gonzalez-Quiroga A, Mesa JA.   +2 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Dual-structure-breaking electrolyte enables practical cadmium-metal battery

Nature Communications
High-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems but face critical challenges of dendrite and corrosion in metal negative electrodes.
Yang-Feng Cui, Hao-Bin Song, Jing-Jing Yao, Qi Hao, Xue-Liang Li, Yi-Fan Li, Bin-Bin Guo, Yun-Hai Zhu, Hui Ying Yang   +8 more
doaj   +1 more source

Ethical Principles in AI Use for Assessment: Exploring Students’ Perspectives on Ethical Principles in Academic Publishing

Education Sciences
Students’ comprehension of ethical principles and their application in the realm of AI technology play a crucial role in shaping the efficacy and morality of assessment procedures.
Alexandra Maria Lazăr (Cățeanu), Angela Repanovici, Daniela Popa, Diana Geanina Ionas, Ada Ioana Dobrescu   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source