Results 91 to 100 of about 12,719,567 (285)

Toward proactive eco-design based on engineer and eco-designer's software interface modeling [PDF]

, 2011
Lien vers la version éditeur: http://www.designsociety.org/publication/30585/toward_proactive_eco-design_based_on_engineer_and_eco-designers_software_interface_modelingIntegrating environmental concerns as well as other constrains (cost, quality, etc ...
RIO, Maud, REYES, Tatiana, ROUCOULES, Lionel   +2 more
core  

Supporting Scenario-Based Product Design: the First Proposal for a Scenario Generation Support Tool [PDF]

, 2009
Organised by: Cranfield UniversityUsing concrete stories about product or technology use, or ‘scenarios’, is a promising design approach. Nevertheless, design practices face uncertainties especially in the activities of identifying, creating and ...
Anggreeni, I., van der Voort, M. C.
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Payload- and Energy-Aware Tactical Allocation Loop-Based Path-Planning Algorithm for Urban Fumigation Robots

Mathematics
Fumigation effectively manages pests, yet manual spraying poses long-term health risks to operators, making autonomous fumigation robots safer and more efficient.
Prithvi Krishna Chittoor, Bhanu Priya Dandumahanti, Abishegan M., Sriniketh Konduri, S. M. Bhagya P. Samarakoon, Mohan Rajesh Elara   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Designed inquiry : the significance of research education for industrial designers

, 2008
Research does not sit comfortably within industrial design practice in either an educational or professional context. This is largely due to the conventions of the clientdesigner relationship and the constraints of design delivery and cost.
Mellick Lopes, Abby (R11243)
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Portable robots for upper-limb rehabilitation after stroke: a systematic review and meta-analysis

Annals of Medicine
Background Robot-assisted upper-limb rehabilitation has been studied for many years, with many randomised controlled trials (RCTs) investigating the effects of robotic-assisted training on affected limbs.
Kevin C. Tseng, Le Wang, Chunkai Hsieh, Alice M. Wong   +3 more
doaj   +1 more source