Results 71 to 80 of about 12,719,567 (285)

Design of a Self-Reconfigurable Drain Mapping Robot With Level-Shifting Capability

IEEE Access, 2020
Nature has always been an inspiration for engineers and designers to have technological inventions. The postures, locomotion and gait cycles of animals are usually smooth, dynamically stable, and highly adaptable in an unknown terrain. Based on a giraffe'
Rizuwana Parween, Abdullah Aamir Hayat, Karthikeyan Elangovan, Koppaka Ganesh Sai Apuroop, Manuel Vega Heredia, Mohan Rajesh Elara   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Robust product design and pricing

Journal of Economic Theory
We study design and pricing by a monopolist who has no information about the distribution of consumers’ tastes and maximizes her profit under the worst-case scenario. We show that her optimal strategy takes a simple form of dividing the taste space into a finite number of equal-length intervals and serving consumers on a randomly chosen interval.
Kyungmin Kim, Nenad Kos
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Developing an Urban Landscape Fumigation Service Robot: A Machine-Learned, Gen-AI-Based Design Trade Study

Applied Sciences
Generative AI (Gen-AI) revolutionizes design by leveraging machine learning to generate innovative solutions. It analyzes data to identify patterns, creates tailored designs, enhances creativity, and allows designers to explore complex possibilities for ...
Prithvi Krishna Chittoor, Bhanu Priya Dandumahanti, Prabakaran Veerajagadheswar, S. M. Bhagya P. Samarakoon, M. A. Viraj J. Muthugala, Mohan Rajesh Elara   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Cultural Echoes in Modern Design: Assessing Young Consumers’ Perceptions of Traditional Bamboo Weaving Patterns

Complexity
This study, employing convenience sampling of art specialists, investigates the emotional resonance of young consumers with Chinese bamboo patterns, underscoring their significance in the realm of contemporary design.
Muxing Gao, Xiaoxiao Cao, Lihuai Qian
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source