Results 71 to 80 of about 4,767,137 (292)

Performance management at design actvity level [PDF]

open access: yes, 2001
The overriding aim of much of the engineering design research is to improve the performance of the design process, and consequently the product development process. Much has been written within the product development literature on the performance of the
Duffy, A.H.B., O'Donnell, F.J.
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

"Silver" product design: Product innovation for older people [PDF]

open access: yes
Aging populations challenge companies across different countries and industries to respond to the changing needs, demands and expectations of their growing shares of older customers.
Bauer, Patrick   +2 more
core  

Novel Cooling Strategy for Electronic Packages: Directly Injected Cooling [PDF]

open access: yes, 2008
This publication discusses domain integration of various engineering disciplines as an effective methodology to design new and innovative products.
Brok, G.J.H.M.   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Integrating Thermodynamics and Biology for Sustainable Product Lifecycle Design [PDF]

open access: yes, 2011
The linkage between raw resources consumption and economic growth through product manufacture and disposal is creating an untenable pressure on the planet’s natural systems; therefore understanding and embracing the mechanics of the biology and physics ...
Conti, Matteo   +3 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Remanufacturing and product design: designing for the 7th generation [PDF]

open access: yes, 2007
The following is taken directly from the research report. This report investigates Design for Remanufacture in terms of both detailed product design and the business context in which Design for Remanufacture may operate.
Charter, Martin, Gray, Casper
core   +1 more source

Parametric modelling of Malaysian teeth template using computer aided design [PDF]

open access: yes, 2016
This study explored a new method and process of design denture using CAD technology to develop a template of a complete denture. Computer aided design were used as a tool of the design process.
ABAS, NOR HASLINDA   +4 more
core   +4 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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