Results 91 to 100 of about 264,030 (261)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Elements of Regulatory Dissonance: Examining FDA and EMA Product Labeling of New Vaccines (2006-2018). [PDF]
Vaccine, 2020 Seo Y, Pacifici E.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Fìlologìčnì traktatiThis article examines the diversity of multimodality, that is, how different sign modes interact in texts. It highlights the importance of understanding the relationship between different modes of symbolic communication, especially in creating a connection between words and images.
openaire +1 more source
What is in a label: Effects of labeling on the preference for plant-based products
AppetiteOur study investigated the effects of three labels on the preference for plant-based products: neutral (plant-based), vegan, and Lenten, referring to products safe to consume during religious fasting. We conducted two experiments to measure the effects of labeling on product preference (Study 1) and actual tasting preferences (Study 2).
Marija Branković +3 more
openaire +3 more sources
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
ZONAL LABELING OF EDGE COMB PRODUCT OF GRAPHS
Jurnal Matematika UNANDGiven a plane graph $G=(V,E)$. A zonal labeling of graph $G$ is defined as an assignment of the two nonzero elements of the ring $\mathbb{Z}_3$, which are $1$ and $2$, to the vertices of $G$ such that the sum of the labels of the vertices on the border ...
Junita Christine Soewongsono +3 more
doaj +1 more source