Results 91 to 100 of about 2,636,574 (342)

A statistical distribution useful in product life-cycle modeling [PDF]

open access: yes
Starting from some recent results presented by Isaic â Maniu and Vodă (2008) regarding the Product Life â Cycle (PLC), we propose here an alternative statistical distribution in order to describe all four phases of a product life span.
Emil PETRESCU
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The environmental and health impacts of tobacco agriculture, cigarette manufacture and consumption. [PDF]

open access: yes, 2015
The health consequences of tobacco use are well known, but less recognized are the significant environmental impacts of tobacco production and use.
Bialous, Stella Aguinaga   +8 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Thesis on Firm Life Cycle, Product Life Cycle, and Retail Life Cycle

open access: yesManagement (Split), 1997
In this paper, the conceptions on firm life cycle, product life cycle and retail life cycle (institution and shop) have been analyzed. Conceptions based on biology have been compared as well. In retail forms specific qualities of particular approaches are described, connected with the efforts of a firm on that development, using price and other ...
openaire   +1 more source

ON A MODEL REGARDING THE PRODUCT LIFE CYCLE [PDF]

open access: yes
In this paper we analyze a modified model for the so-called PLC – Product Life Cycle, the original model being proposed by N. Al. Pop (2000). This PLC is considered here from a reliability theory viewpoint: our modification lies in the fact that the PLC -
Alexandru ISAIC-MANIU, Viorel Gh. VODĂ
core  

Sustainable product development strategies: Business planning and performance implications [PDF]

open access: yes, 2012
Copyright © 2012 by Institution of Mechanical Engineers. This is the author's accepted manuscript. The final published article is available from the link below.Manufacturing firms are under many financial and competitive pressures which focus attention ...
Aurich JC   +6 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Life cycle assessment of emerging mass timber product: Cross-laminated bamboo

open access: yesCleaner Environmental Systems
Cross-laminated bamboo (CLB) is a new type of mass timber product that can be a substitute for traditional non-renewable construction materials. This study conducted a cradle-to-grave life cycle assessment (LCA) to quantify the environmental impacts of ...
Yinqiao Wang, Kai Lan
doaj   +1 more source

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