Results 111 to 120 of about 1,817,007 (304)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Simulating Life Cycles of Individual Products for Life Cycle Design
Procedia CIRP, 2015 AbstractMinimizing environmental loads and resource consumption is a major issue in the manufacturing industry while enhancing value of products. Individual products have a variety of states depending on their life cycle histories even if they are produced from the same design information. While design information represents their ‘nominal information’
Matsuyama, Yuki +2 more
openaire +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Industry 4.0 Engineering Product Life Cycle Management Based on Multigranularity Access Control Model. [PDF]
Comput Intell Neurosci, 2022 Yu L, Zhu S.
europepmc +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Cykl życia produktu – od marketingu, przez kreację handlu do raportowania ESG
Studia i MateriałyPurpose: The purpose of this article is to present the meaning of the term “Product Life Cycle” (PLC) in various fields of science and practical business applications.
Michał Kołtuniak, Iwona Sroka
doaj +1 more source
Patient Preference Studies for Advanced Prostate Cancer Treatment Along the Medical Product Life Cycle: Systematic Literature Review. [PDF]
Patient Prefer Adherence, 2022 Menges D, Piatti MC, Cerny T, Puhan MA.
europepmc +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A multi-stage supply chain disruption mitigation strategy considering product life cycle during COVID-19. [PDF]
Environ Sci Pollut Res Int, 2022 Chen J, Wang H, Fu Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source