Results 121 to 130 of about 2,636,574 (342)

Environmental footprints of disposable and reusable personal protective equipment ‒ a product life cycle approach for body coveralls. [PDF]

J Clean Prod, 2023
Snigdha, Hiloidhari M, Bandyopadhyay S.
europepmc   +1 more source

Market performance and competition: A product life cycle model [PDF]

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Werker, Claudia
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Medicine shortages: Product life cycle phases and characteristics of medicines in short supply-A register study. [PDF]

Front Pharmacol, 2022
Sarnola K, Kari H, Koskinen H.
europepmc   +1 more source

Technology Development and Product Life Cycle: The Case of Counter-pressure Casting in Bulgaria [PDF]

, 1989
This paper presents the second part of the case study developed at the Metals Technology Company, in Bulgaria, which created and is applying the new original Bulgarian technology of casting by counter-pressure.
Djarova, J., Nenov, I., Tonchev, T.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Cykl życia produktu – od marketingu, przez kreację handlu do raportowania ESG

Studia i Materiały
Purpose: The purpose of this article is to present the meaning of the term “Product Life Cycle” (PLC) in various fields of science and practical business applications.
Michał Kołtuniak, Iwona Sroka
doaj   +1 more source

Industry 4.0 Engineering Product Life Cycle Management Based on Multigranularity Access Control Model. [PDF]

Comput Intell Neurosci, 2022
Yu L, Zhu S.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source