Results 41 to 50 of about 1,817,007 (304)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Adaptation of corporate model of ukrainian aircraft product life cycle to the international methodology of systems engineering

Mechanics and Advanced Technologies, 2023
Problems. Under the present-day conditions, the preservation of competences of Ukrainian aircraft construction enterprises will be determined by the possibility of enterprises attracting to participation in international cooperation programs and ...
Svitlana Kryvova, Constantine Zvorykin, Serhii Trubachev   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Environmental Performance of Kettle Production: Product Life Cycle Assessment

Management Systems in Production Engineering, 2017
The main objective of this paper is to compare the environmental impact caused by two different types of water boiling processes. The aim was achieved thanks to product life cycle assessment (LCA) conducted for stovetop and electric kettles. A literature
Marcinkowski Andrzej, Zych Krzysztof
doaj   +1 more source

Environmental scenario as approach for achieving sustainability in product design

Journal of Architecture, Art & Humanistic Science, 2019
Scenario is one of the most effective design tools and methods used to predict areas of success and failure in product design, it gives predictions about the life cycle and trajectory of the product during each stage, as the scenario is a futuristic tool
Osama Mohamed
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Enhanced product functionality with life cycle units [PDF]

, 2003
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Buchholz, A., Kross, U., Seliger, Günther   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Blockchain-enabled product life cycle assessment information management system

Ain Shams Engineering Journal
Life Cycle Assessment (LCA) often faces challenges such as low data transparency, limited traceability, and poor data sharing among entities. To address these issues, this study develops a blockchain based life cycle information management system that ...
Jun Zhou, Yajun Duan
doaj   +1 more source

Product Life Cycle concept use and application by marketing decision-makers in small South African organisations

Acta Commercii, 2003
The purpose of the study was to test the underlying theory of the product life cycle concept with the primary objective of establishing what the use and practical value of the product life cycle concept is in making marketing decisions in small ...
F. J. Herbst
doaj   +1 more source