Results 61 to 70 of about 2,636,574 (342)
, 2009 The density function of product life cycles in convenience stores is found to follow the Weibull distribution. To clarify the parameters that determine these life cycles, we introduce the conditional market share-defined as the probability that a product
Mizuno, Takayuki, Takayasu, Misako
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Supply chain implications of sustainable design strategies for electronics products [PDF]
, 2012 Increasing legislative and consumer pressures on manufacturers to improve sustainability necessitates that manufacturers consider the overall life cycle and not be scope restricted in creating products.
Bateman, RJ, De Coster, R, Plant, AVC
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Life cycle perspective in design and product development
Engineering Management in Production and ServicesEco-design is one of the cornerstones of the modern economy, as reflected in the policies aimed at implementing the principles of design for the environment in the European Union legislation. A life cycle perspective is a feature of eco-design. The study
Joachimiak-Lechman Katarzyna
doaj +1 more source
Intelligent Human Machine Interface Design for Advanced Product Life Cycle Management Systems
, 2009 Designing and implementing an intelligent and user friendly human machine interface for any kind of software or hardware oriented application is always be a challenging task for the designers and developers because it is very difficult to understand the ...
Ahmed, Zeeshan
core +1 more source
Integrated Application of the Target Co-sting and Life Cycle Costing in Contemporary Business Environment [PDF]
, 2015 Contemporary business environment is characterized by frequent changes in business conditions. Technological innovations and changes in customers’ perception affect on the continuous improvement in quality, availability and functionality of the product ...
Hrvoje Perčević +2 more
core +2 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
SUATU PENDEKATAN BARU DALAM PRODUCT DEVELOPMENT COSTING UNTUK BARANG-BARANG INDUSTRI
Jurnal Akuntansi dan Keuangan, 1999 In the very competitive bussiness environment, the company ability to create or develop its product is an important thing to keep. With the competitivenes of each product, especially industrial product, each product has a short life-cycle. The life-cycle
Monika Kussetya Ciptani
doaj