Results 31 to 40 of about 73,209 (264)

Product/Business Portfolio management: Logic, structural, and managerial implications

South African Journal of Business Management, 1985
The objective and scope of this article are to discuss the logic of Product/Business Portfolio management and to demonstrate how the expected optimal results of such management are undermined, if not completely undermined by factors which are ...
S. Shabalala
doaj   +1 more source

Probabilistic modal {\mu}-calculus with independent product [PDF]

Logical Methods in Computer Science, 2012
The probabilistic modal {\mu}-calculus is a fixed-point logic designed for expressing properties of probabilistic labeled transition systems (PLTS's). Two equivalent semantics have been studied for this logic, both assigning to each state a value in the ...
Matteo Mio
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Sum and Product in Dynamic Epistemic Logic [PDF]

Journal of Logic and Computation, 2007
The Sum-and-Product riddle was first published in the reference H. Freudenthal (1969, Nieuw Archief voor Wiskunde 3, 152) [6]. We provide an overview on the history of the dissemination of this riddle through the academic and puzzle-math community.
van Ditmarsch, H.P., Ruan, J, Verbrugge, Rineke   +2 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A Translation of Weighted LTL Formulas to Weighted Buchi Automata over omega-valuation Monoids

Scientific Annals of Computer Science, 2021
In this paper we introduce a weighted LTL over product omega-valuation monoids that satisfy specific properties. We also introduce weighted generalized Buchi automata with epsilon-transitions, as well as weighted Buchi automata with epsilon-transitions ...
Eleni Mandrali
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source