Results 111 to 120 of about 6,354,822 (301)

Modified Stage-Gate: A Conceptual Model of Virtual Product Development Process [PDF]

, 2011
In today s dynamic marketplace, manufacturing companies are under strong pressure to introduce new products for long-term survival with their competitors.
Ahmed, Shamsuddin, Ebrahim, Nader Ale, Taha, Zahari   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A quantitative model of hierarchical product design

Design Science
Analysing hierarchical design processes is difficult due to the technical and organizational dependencies spanning over multiple levels. The V-Model of Systems Engineering considers multiple levels. It is, however, not quantitative.
Ferdinand Wöhr, Simon Königs, Max Stanglmeier, Markus Zimmermann   +3 more
doaj   +1 more source

Finite-dimensional representation of the quadratic algebra of a generalized coagulation-decoagulation model

, 2008
The steady-state of a generalized coagulation-decoagulation model on a one-dimensional lattice with reflecting boundaries is studied using a matrix-product approach.
Ali Aghamohammadi, Belitsky V, Blythe R A, Farhad H Jafarpour, Ferrari P A, Hinrichsen H, Jafarpour F H, Jafarpour F H, Krebs K, Paessens M, Tabatabaei F   +10 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

IHO S-100 Data Model and Relevant Product Specification [PDF]

TransNav
The International Hydrographic Organization (IHO) has established a new hydrographic information standard, the S-100 standard. This standard applies the ISO 19100 series to the legacy hydrographic exchange standard in order to overcome the limitations of
Seojeong Lee, Hyoseung Kim
doaj   +1 more source

Dual Attention Network for Product Compatibility and Function Satisfiability Analysis

, 2017
Product compatibility and their functionality are of utmost importance to customers when they purchase products, and to sellers and manufacturers when they sell products.
Shu, Lei, Xie, Sihong, Xu, Hu, Yu, Philip S.   +3 more
core   +1 more source

Quantum Cournot equilibrium for the Hotelling-Smithies model of product choice

, 2012
This paper demonstrates the quantization of a spatial Cournot duopoly model with product choice, a two stage game focusing on non-cooperation in locations and quantities.
Al-Nowaihi A, B Basu, Ball P, Prevedel R, Priyadarshi Majumdar, Ramij Rahaman, Schmid C   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source