Results 51 to 60 of about 307,174 (218)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Red palm olein biscuit supplementation modulates gut microbiota in vitamin A deficient rural Malaysian schoolchildren: a randomised controlled trial

Nature Communications
Emerging evidence suggests a bidirectional relationship between vitamin A deficiency (VAD) and gut microbiota, with implications to host health. This double-blind randomised controlled trial (NCT03256123) aims to investigate the effects of 6-month red ...
Pei Yee Tan, Radhika Loganathan, Soo Ching Lee, Syahirah Nadiah Mohd Johari, Kim-Tiu Teng, Kanga Rani Selvaduray, Yvonne Ai-Lian Lim   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Pilot-scale experimental research on mixing characteristics of methanol and refined products in batch transportation

You-qi chuyun
ObjectiveAgainst the backdrop of the “dual carbon” goals, methanol holds significant potential as a clean liquid fuel and hydrogen carrierfor large-scale pipeline transport.
Shujuan QIU, Yunchen WANG, Xiaolong LI, Yixuan WANG, Qiang LI, Jian LI, Hengyang LIU, Wenyuan SUN   +7 more
doaj   +1 more source

Effect of Deoxynivalenol Contamination on the Safety, Quality Indexes and Utilization Rate of Wheat [PDF]

Shipin Kexue
In this study, 17 deoxynivalenol (DON) contaminated wheat samples were assessed for safety and quality index such as unit weight, water absorption of gluten, crude protein content, unsound kernel content, sprouted kernel content, gibberella damaged ...
ZHANG Chun’e, LIAO Ruoyu, LIU Xinbao, NIU Ying, SUN Yue, GUO Baoyuan
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

The Impact of pasteurization on tetracycline residues, physicochemical, microbiological, and antioxidant properties of acacia honey

Menara Perkebunan
Honey is recognized for its high nutritional and functional value, yet it remains vulnerable to contamination by antibiotic residues such as tetracycline when beekeeping practices are not properly managed.
Fuad Al Alfarisi, Abdul Manab, Fitri Amalia, Woro Dyah Pinilih, Metrizal, Firda Dimawarnita   +5 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Effects of Indonesian Shortfin Eel (Anguilla bicolor) By-Product Oil Supplementation on HOMA-IR and Lipid Profile in Obese Male Wistar Rats. [PDF]

Nutrients, 2023
Megawati G, Syahruddin SS, Tjandra W, Kusumawati M, Herawati DMD, Gurnida DA, Musfiroh I.   +6 more
europepmc   +1 more source