Results 41 to 50 of about 125,701 (217)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Progress of research on diffusion rules of spilled oil from onshore oil pipeline and leakage consequences

You-qi chuyun, 2020
Oil pipeline leakage will cause direct economic losses and even adversely affect the surrounding environment and residents along the pipeline. It is crucial to be aware of the seepage, surface diffusion and evaporation of leaked oil in the surrounding ...
Shengli LIU, Yongtu LIANG, Xiao WANG
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

The behavior of a co-flow structure to screen projects in a product pipeline

GEPROS: Gestão da Produção, Operações e Sistemas, 2016
In many situations, System Dynamics modelers have to capture attributes of items tracked in an aging chain by means of a co-flow. This study presents an application of co-flows in aging chains: A co-flow that enables the process of screening, i.e.
Paulo S. Figueiredo, Elisabeth Loiola
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Simulation of Soil Temperature and Pipeline Temperature-Pressure after Shutdown of J-Y Product Pipeline

Shiyou huagong gaodeng xuexiao xuebao
During the shutdown period of the J-Y refined oil product pipeline, there is a significant difference between the temperature of the transported oil and the outside soil temperature, which leads to a pressure drop in the pipeline after the shutdown. When
Yanchao WEI, Yuerong WU, Dongjun LI, Yuefeng WU, Na KOU, Xiaoping LI, Bingyuan HONG   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Current status and prospects of technological development for batch transportation of methanol via product oil pipelines

You-qi chuyun
ObjectiveWith the accelerated implementation of carbon peaking and carbon neutrality strategies, the consumption mix of traditional oil and gas resources has undergone significant changes, reflected in a slowing growth rate of oil and gas demand and a ...
Weibin WANG, Kuirong LIU, Yuxing LI
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Analysis of parameter adaptability for multi-product pipelines with high heads transformed into liquid ammonia transmission system

You-qi chuyun
ObjectiveThe imbalance of renewable energy distribution in China brings significant mismatches between ammonia supply and demand. Since the routes of multi-product pipelines largely align with the supply directions of ammonia energy, converting these ...
Mingyue HUANG, Renfu TU, Qi LIAO, Weilong NI, Zhengbing LI, Hao ZHANG, Bin XU, Yongtu LIANG   +7 more
doaj   +1 more source