Results 101 to 110 of about 610,727 (313)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Low storage space for compressive sensing: semi-tensor product approach

open access: yesEURASIP Journal on Image and Video Processing, 2017
Random measurement matrices play a critical role in successful recovery with the compressive sensing (CS) framework. However, due to its randomly generated elements, these matrices require massive amounts of storage space to implement a random matrix in ...
Jinming Wang   +3 more
doaj   +1 more source

Space is the machine: a configurational theory of architecture

open access: yes, 2007
Since The social logic of space was published in 1984, Bill Hillier and his colleagues at University College London have been conducting research on how space features in the form and functioning of buildings and cities. A key outcome is the concept of â€
Hillier, B, Hillier, Bill
core  

The Product Space Revisited: China's Trade Profile [PDF]

open access: yes, 2015
The concept of product space has encountered broad interest within the development community, as an analytical tool against which to assess countries' potential to diversify their production and export structures.
Scaramozzino, Pasquale   +7 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Is the product of CCC spaces a CCC space?

open access: yesPublicacions Matemàtiques, 1989
In this expository paper it is shown that Martin's Axiom and the negation of the Continuum Hypothesis imply that the product of ccc spaces is a ccc space. The Continuum Hypothesis is then used to construct the Laver-Galvin example of two ccc spaces whose product is not a ccc space.
openaire   +5 more sources

Space Product Development Process: Integrating a Sustainability Perspective in Design and Production of Spacecraft

open access: yes, 2022
Technological advancements and the growing demand for global connectivity is leading to an explosive growth of satellites being launched into space.
Laufer, René,   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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