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Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Guia de la Jurisprudència espanyola sobre Productes Defectuosos

InDret, 2008
Joan Carles Seuba Torreblanca
doaj  

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Microelectronics in products and production

Robotics, 1985
This paper discusses the introduction of microelectronics for innovation of products and production processes as well as its influences on structural changes in the factories. Examples and tendencies for technical changes in products, material flow and information flow are shown.
Hans-Jürgen Warnecke, R.-J. Knappmann
openaire   +1 more source

Production, Service, and Productivity

Psychological Reports, 1966
The author shows how, via a linear-programming approach, a life-insurance company can determine objectively minimum and maximum limits for optimum debit size. The requirements are two policy decisions (the minimum allowable compensation and the minimum allowable productivity level) and the determination of the functional relation between sales ...
openaire   +2 more sources

Products of Commutators in Free Products

International Journal of Algebra and Computation, 1997
The genus of an element in the commutator subgroup of a group \(G\) is the minimal number of commutators of which the element is a product. It has been shown previously that in a free group each element of genus \(n\) can be obtained by permutation and suitable substitution on one of a finite number of words called orientable forms of genus \(n\).
openaire   +3 more sources

Products as product lines

2013 4th International Workshop on Product LinE Approaches in Software Engineering (PLEASE), 2013
An argument is made that a product line approach can be beneficial for even single product development, particularly for products that support customers whose needs are likely to change over time. Furthermore, product line techniques for identifying requirements and design alternatives and documenting rationale for decisions would benefit any product ...
openaire   +1 more source

PRODUCTS

Environmental Science & Technology, 1983
  +13 more sources

Products

Computer, 2006
  +6 more sources

Products

Nursing Standard, 1992
Algutat, a new haemostatic absorbent for use in surgery, has been produced by BritCair.
openaire   +2 more sources