Results 141 to 150 of about 3,657,739 (234)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Chaperone overexpression boosts heterologous small molecule production in Saccharomyces cerevisiae. [PDF]

Microb Cell Fact
Vestergaard AM, Nurani W, Cachera P, Mortensen UH.   +3 more
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

On the coincidence of weather extremes and geopolitical conflicts: Risk analysis in regional food markets. [PDF]

PLoS One
Arreyndip NA, Pal JS.
europepmc   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Guest Foreword from Michael Thomas CMG QC

International Review of Law, 2019
ojsadmin production
doaj  

Effects of Plantain (<i>Plantago lanceolata</i> L.) Metabolites Aucubin, Acteoside, and Catalpol on Methane Emissions <i>In Vitro</i>. [PDF]

J Agric Food Chem
Sivanandarajah K, Donaghy D, Kemp P, Navarrete S, Horne D, Ramilan T, Molano G, Pacheco D.   +7 more
europepmc   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Table of Contents

مجلة العلوم التربوية
ojsadmin production
doaj   +1 more source

"I Have No Idea What's in It!"-A Qualitative Study of Adolescents' Conceptions of Milk Alternatives. [PDF]

Food Sci Nutr
Szczepanski L, Stonner I, Fiebelkorn F.
europepmc   +1 more source