Results 111 to 120 of about 3,105,445 (332)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Decision letter for "<scp>CRISPR‐Cas9</scp> mediated engineering of <i>Bacillus licheniformis</i> for industrial production of ( <scp>2R</scp> , <scp>3S</scp> )‐butanediol"

, 2020

openalex   +1 more source

Experience in the application of the non-destructive method of acoustic emission in the production of titanium billets and products of transport engineering

, 2021
E. Yu. Remshev, A I Olehver, Sergey Voinash, В А Соколова, А. А. Иванов, V N Malikov, T N Vagizov   +6 more
openalex   +1 more source

Transforming ERP interfaces in production environments: An empirical evaluation using the User Experience Questionnaire

Applied Computer Science
This study aims to evaluate the user experience (UX) of Enterprise Resource Planning (ERP) system modules in Polish enterprises' information and communication technology-based production environments.
Anna HAMERA
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Engineering Trust - Reciprocity in the Production of Reputation Information [PDF]

Reciprocal feedback distorts the production and content of reputation information, hampering trust and trade efficiency. Data from eBay and other sources combined with laboratory data provide a robust picture of how reciprocity can be guided by changes ...
Axel Ockenfels, Ben Greiner, Gary E. Bolton   +2 more
core  

Special Issue of the 2014 (5th) International Conference on Engineering, Project, and Production Management. [PDF]

Journal of Engineering, Project, and Production Management, 2015
This issue includes five papers, four of which were selected from the 2014 (5th) International Conference on Engineering, Project, and Production Management (EPPM2014) held in Port Elizabeth, South Africa, and three of which won the EPPM2014 Excellent ...
Ko, C. H.
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

BIOMASS FOR ELECTRICITY AND PROCESS HEAT AT ETHANOL PLANTS [PDF]

Published in: Applied Engineering in Agriculture, Vol. 22(5): 723-728Biomass, Process heat, Ethanol production, Electricity, Combined heat and power, Resource /Energy Economics and Policy,
Hatfield, Dennis L., Morey, R. Vance, Tiffany, Douglas G.   +2 more
core   +1 more source

Qualitative-environmental aspects of products improvement in SMEs from V4 countries

Production Engineering Archives
Sustainable development has caused companies to try to adapt their activities to changing customer expectations, but also to climate change. This poses a particular challenge for SMEs from developing countries.
Siwiec Dominika, Pacana Andrzej, Gavurová Beáta, Ključnikov Aleksandr, Nagy Szabolcs   +4 more
doaj   +1 more source