Results 141 to 150 of about 3,105,445 (332)

Incentive Regulation and the Role of Convexity in Benchmarking Electricity Distribution: Economists versus Engineers [PDF]

This note illustrates the potential impact of the specification of a convex production technology on establishing minimal costs compared to the use of a non-convex technology when benchmarking electricity distributors.
Emili Grifell-Tatjé, Kristiaan Kerstens
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Solar photochemical process engineering for production of fuels and chemicals [PDF]

The engineering costs and performance of a nominal 25,000 scmd (883,000 scfd) photochemical plant to produce dihydrogen from water were studied. Two systems were considered, one based on flat-plate collector/reactors and the other on linear parabolic ...
Biddle, J. R., Fujita, T., Peterson, D. B.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Railway engineering and production of electric trains in the context of import substitution

, 2023
В. Н. Борисов, Daria Plotnikova
openalex   +2 more sources

OPTIMAL IRRIGATION PIVOT LOCATION ON IRREGULARLY SHAPED FIELDS [PDF]

Although annual rainfall in the Southeast is adequate, its distribution is a potential constraint to agricultural production. Farmers require production information concerning efficient use of irrigation technology adapted to regional growing conditions.
Hardy, William E., Jr., Hatch, L. Upton, Johnson, Gregory C., Rochester, Eugene W.   +3 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Process engineering of pH tolerant Ustilago cynodontis for efficient itaconic acid production [PDF]

, 2019
Hamed Hosseinpour Tehrani, Katharina Maria Saur, Apilaasha Tharmasothirajan, Lars M. Blank, Nick Wierckx   +4 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Metabolic engineering of Corynebacterium crenatum for enhanced L-tyrosine production from mannitol and glucose [PDF]

Yang Gang, Sicheng Xiong, Mingzhu Huang, Bin Liu, Yanna Shao, Xuelan Chen   +5 more
openalex   +1 more source