Results 181 to 190 of about 3,105,445 (332)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

PRACTICE OF REALIZATION OF REAL PRODUCTION TASKS ON REVERSE ENGINEERING WITHIN THE FRAMEWORK OF EXECUTION OF COURSE PROJECTS BY STUDENTS OF SPECIALTY 015 VOCATIONAL EDUCATION (COMPUTER / DIGITAL TECHNOLOGIES)

, 2021
Дмитро Вікторович Соменко, Olena Somenko   +1 more
openalex   +2 more sources

Product line engineering: Product derivation

, 2002
Handling the various derivations of a product can be a daunting (and costly) task. To tackle this problem, we propose a method based on the use of creational design patterns to uncouple the variations (reified as language-level objects) from the selection process.
Monestel, Laurent, Ziadi, Tewfik, Jézéquel, Jean-Marc   +2 more
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Retraction: Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives. [PDF]

RSC Adv
Budhiraja M, Chudasama B, Ali A, Tyagi V.   +3 more
europepmc   +1 more source

Digital support of production small business preparation in engineering [PDF]

, 2019
V. F. Bulavin, T.G. Bulavina, V V Yahrichev, A.S. Stepanov, Aleksey A. Frolov   +4 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Integrating synthetic biology and process engineering for enhanced isobutanol biosynthesis yield and sustainability. [PDF]

Biotechnol Biofuels Bioprod
Chen J, Hao J, Baganz F.
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Paradigm Shift in Microbial Protein Manufacturing. [PDF]

Life (Basel)
Zhuo X, Xie Y, Yu J, Xue W, Weng Y, Tong S.   +5 more
europepmc   +1 more source