Results 81 to 90 of about 723,137 (243)

Special Issue of the 2014 (5th) International Conference on Engineering, Project, and Production Management. [PDF]

Journal of Engineering, Project, and Production Management, 2015
This issue includes five papers, four of which were selected from the 2014 (5th) International Conference on Engineering, Project, and Production Management (EPPM2014) held in Port Elizabeth, South Africa, and three of which won the EPPM2014 Excellent ...
Ko, C. H.
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Qualitative-environmental aspects of products improvement in SMEs from V4 countries

Production Engineering Archives
Sustainable development has caused companies to try to adapt their activities to changing customer expectations, but also to climate change. This poses a particular challenge for SMEs from developing countries.
Siwiec Dominika, Pacana Andrzej, Gavurová Beáta, Ključnikov Aleksandr, Nagy Szabolcs   +4 more
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Generating An Automated Assembly Graph On The Basis Of The 3D-Geometry Of A Product Assembly Group

Proceedings of the Conference on Production Systems and Logistics
In an era of globalisation and worldwide competition, it is essential for companies to develop competitive and cost-effective products. To achieve this goal, early selection between different product concepts is crucial. Despite proven methods in product
Disselkamp, Jan-Philipp, Lick, Jonas, Azem, Ghayth, Grothe, Robin, Ptock, Lukas, Meyer, Matthias, Kürpick, Dominik, Hovemann, Aschot, Dumitrescu, Roman, Herberger, David, Hübner, Marco   +10 more
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Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Effect of Single-Point Incremental Forming Process Parameters on Roughness of the Outer Surface of Conical Drawpieces from CP Titanium Sheets

Advances in Mechanical and Materials Engineering
With the widespread use of numerically controlled machine tools, single-point incremental forming (SPIF) process has enjoyed growing interest in the industry.
Marcin Szpunar, Robert Ostrowski, Department of Manufacturing and Production Engineering, Faculty of Mechanical Engineering and Aeronautics, Rzeszów University of Technology, al. Powstancow Warszawy 8, 35-959 Rzeszow, Poland   +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Engineering, Project, and Production Management: Lessons [PDF]

Journal of Engineering, Project, and Production Management, 2013
This Journal always faces the challenge of bringing together the three disciplines in a common pool of management research. This edition provides at least a paper in each of the disciplines.
Kassim Gidado
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PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source