Results 101 to 110 of about 12,429,939 (247)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

How accessible is the STEM post 16 education provision, the pipeline to computing and engineering programmes? [PDF]

open access: yes, 2019
EngineeringUK (2018) are estimating UK has an engineering graduate-level shortfall of at least 22,000 per year, the Royal Academy is reporting that by 2024 the engineering shortfall in the UK will be 160,000.
Stallard, J.A.   +2 more
core  

Service Computing System Engineering Life Cycle [PDF]

open access: yes, 2017
The development of service computing technology has triggered the need for organizations to build a service computing system. This system is able to deliver IT services that can meet the challenges and needs of business services.
Suhardi, Suhardi; Institut Teknologi Bandung Bandung   +2 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Engineering applications of soft computing

open access: yes, 2017
This book bridges the gap between Soft Computing techniques and their applications to complex engineering problems. In each chapter we endeavor to explain the basic ideas behind the proposed applications in an accessible format for readers who may not ...
Díaz-Cortés, Margarita-Arimatea   +5 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Soft computing techniques in engineering applications

open access: yes, 2014
The Soft Computing techniques, which are based on the information processing of biological systems are now massively used in the area of pattern recognition, making prediction & planning, as well as acting on the environment.
Zhong, Baojiang, Patnaik, Srikanta
core   +1 more source

Agent‐based simulation system for optimising resource allocation in production process

open access: yesIET Collaborative Intelligent Manufacturing
Efficient sequencing of processes and resource allocation are critical in production planning scenarios, such as manufacturing workshops and construction projects, to enhance efficiency and reduce operational costs.
Jingjing Zhao, Fan Zhang
doaj   +1 more source

A multi-objective analytics approach for supply chain optimization in flexible manufacturing systems

open access: yesSupply Chain Analytics
This study contributes to the advancement of supply chain scheduling (SCS) through the development of a comprehensive mathematical framework that unifies multi-objective supplier selection, demand allocation, production scheduling, and inventory ...
Shahed Mahmud   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

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