Results 111 to 120 of about 13,118,916 (332)

Equipment Identification and Localization Method Based on Improved YOLOv5s Model for Production Line. [PDF]

Sensors (Basel), 2022
Yu M, Wan Q, Tian S, Hou Y, Wang Y, Zhao J.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Educational Case Studies: Creating a Digital Twin of the Production Line in TIA Portal, Unity, and Game4Automation Framework. [PDF]

Sensors (Basel), 2023
Balla M, Haffner O, Kučera E, Cigánek J.   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Stochastic Modeling of Operation Time Under Production Risks Depending on the Size of the Processed Batch of Parts

Applied Sciences
This article addresses the problem of production risk assessment in linear manufacturing systems, considering the stochastic nature of equipment downtime and variability in processing times.
Oleh Pihnastyi, Anna Burduk, Phatchani Srikhumsuk   +2 more
doaj   +1 more source

Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line. [PDF]

Front Microbiol, 2023
Krüger GI, Pardo-Esté C, Zepeda P, Olivares-Pacheco J, Galleguillos N, Suarez M, Castro-Severyn J, Alvarez-Thon L, Tello M, Valdes JH, Saavedra CP.   +10 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Biomimetic Regulation in Supply Chains and Production Systems

Advanced Intelligent Systems
The production industry is challenged to become more flexible and efficient while coping with a variety of disruptive events, such as natural disasters, infrastructure blockages, or economic crises. From the individual station on a production line to the
Marc Thielen, Niclas Trube, Johannes M. Schneider, Malte von Ramin   +3 more
doaj   +1 more source

Building up libraries and production line for single atom catalysts with precursor-atomization strategy. [PDF]

Nat Commun, 2022
He X, Zhang H, Zhang X, Zhang Y, He Q, Chen H, Cheng Y, Peng M, Qin X, Ji H, Ma D.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source