Results 101 to 110 of about 14,911,565 (309)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Alocação de modelos de produtos a equipes de trabalhadores baseada em modelos de curvas de aprendizagem Assignment of product models to worker teams using learning curve models

open access: yesProduction, 2005
Em ambientes de alta customização, uma grande variedade de modelos de produtos é demandada pelos consumidores. Essa condição exige uma rápida adequação dos meios produtivos às especificações do próximo modelo a ser produzido.
Michel José Anzanello   +1 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Quality–Cost–Environment Assessment of Sustainable Manufacturing of Photovoltaic Panels

open access: yesEnergies
This paper aims to develop an integrated Quality–Cost–Environmental (QCE) indicator for the selection of photovoltaic panels (PVps) offered to customers, considering the following criteria: (i) quality satisfaction; (ii) cost-effectiveness; and (iii ...
Remigiusz Gawlik   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Models of Quality Management applied to organizations seeking to Innovation Management. [PDF]

open access: yes, 2013
The Total Quality Management seeks constant improvement and a gradual introduction of new processes both as existing in order to achieve greater excellence in quality organizations as a whole. The intensity of global competition has required companies to
Sartori, Tatiane   +2 more
core  

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