Results 211 to 220 of about 19,558,547 (301)

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Recent advances in the biosynthesis and production optimization of gentamicin: A critical review. [PDF]

Synth Syst Biotechnol
Xu F, Hu K, Mohsin A, Wu J, Su L, Wang Y, Ben R, Gao H, Tian X, Chu J.   +9 more
europepmc   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Eco-Friendly Biocomposites from Chestnut Waste: Production, Optimization, Characterization, and Application. [PDF]

Polymers (Basel)
Silva SB, Freitas OM, Vieira EF, Gomes A, Carreiras AR, Moreira DC, Esfandiari P, Silva JF, Delerue-Matos C, Domingues VF.   +9 more
europepmc   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Production, optimization and characterization of esterase isolated from a new endophytic Trichoderma afroharzianum strain AUMC 16,433 and its applications in dye decolorization. [PDF]

Microb Cell Fact
Mahmoud YA, Alamin NS, Mohamed TM, El-Zawawy NA, Salem MM.   +4 more
europepmc   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Development of an efficient expression system for human chaperone BiP in Pichia pastoris: production optimization and functional validation. [PDF]

Microb Cell Fact
Žitkus E, Čiplys E, Žiaunys M, Sakalauskas A, Slibinskas R.   +4 more
europepmc   +1 more source

Extracellular polysaccharide from Weissella confusa OF126: Production, optimization, and characterization.

International Journal of Biological Macromolecules, 2018
A. Adesulu-Dahunsi, A. Sanni, K. Jeyaram, J. Ojediran, A. Ogunsakin, K. Banwo   +5 more
semanticscholar   +1 more source