Results 51 to 60 of about 2,279,555 (304)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Controlling a group of microCHPs: planning and realization [PDF]

, 2011
This paper discusses the planning problem of a group of domestic Combined Heat and Power (microCHP) appliances, which together form a Virtual Power Plant (VPP).
Bakker, Vincent, Bosman, Maurice G.C., Hurink, Johann L., Molderink, Albert, Smit, Gerard J.M.   +4 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Plan maestro de producción basado en programación lineal entera para una empresa de productos químicos || Master Production Scheduling Based on Integer Linear Programming for a Chemical Company

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2017
En este trabajo se propone un modelo de programación lineal entera para planificar la producción de un conjunto de artículos finales con demanda independiente.
Reyes Zotelo, Yunuem, Mula, Josefa, Díaz-Madroñero, Manuel, Gutiérrez González, Eduardo   +3 more
doaj  

New approach to the design of mining operations [PDF]

, 2019
Analysis of the production development scenarios is proposed for strategic activity planning; criteria to make decisions under the uncertainty conditions as well as decision-making trees for day-to-day management are proposed to determine balanced ...
Hrinov, V., Khorolskyi, A., Mamaikin, O.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

What is a good plan? [PDF]

, 2015
The word plan is in English both a verb and a noun, reminding us that to plan is a process resulting in a product, a plan. While the Last Planner System (LPS) is primarily focused on how to plan and control production, other planning concepts are more
Aslesen, Sigmund, Bølviken, Trond, Koskela, Lauri   +2 more
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

A fuzzy goal programming for dynamic cell formation and production planning problem together with pricing and advertising decisions

International Journal of Industrial Engineering and Production Research, 2020
In this paper, an integrated mathematical model of the dynamic cell formation and production planning, considering the pricing and advertising decision is proposed.
saeed dehnavi, ahmad sadegheih
doaj