Results 221 to 230 of about 1,415,684 (317)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Management practices of five U.S. sheep breeds: insights from a producer survey. [PDF]

Transl Anim Sci
Gunes HY, Murphy TW, Wilson CS, Freking BA, Burke JM, Taylor JB, Brito LF, Lewis RM.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Galactooligosaccharides Based on β-Galactosidase-Catalyzed Synthesis: Function, Biosynthesis and Optimization Strategy. [PDF]

Foods
Tao B, Chen Y, He R, Huang T, Liang S, Chen H, Rao X, Tang X, Jiang J.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

International multisite implementation of distributed cell-free protein biomanufacturing to advance health and research equity. [PDF]

Sci Adv
da Silva SJR, Matthews Q, Cazaux S, Vigar JRJ, Santos BNR, Carvalho DCM, Cranmer LA, Duplat D, Singh S, Simchi M, Benítez-Bolivar P, de Lima Cavalcanti TYV, Wu K, Mendes RPG, Kale T, Divarzak ALL, Bozovicar K, Doucet J, Arce A, Léon C, Ferrando V, Nguyen J, Ho A, de Lima SC, Bayat P, Guo Y, Cicek S, Tinafar A, Krokovsky L, Machado LC, Rayhan A, Iwe IA, Klenov A, de Araujo TPG, Nascimento JPM, Magalhães JJF, Guevara-Suarez M, Garcia Canete P, Ayi K, Charania M, Stehelin TE, Chatfield-Reed K, Paiva MHS, Crandall I, Mazzulli T, da Luz Wallau G, Silva-Júnior A, Bernal A, Athale CA, Green AA, Weaver SC, González C, Federici F, Pena L, Pardee K.   +54 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

CFD-aided design and hydrodynamic characterization of a single-use perfusion bioreactor for high density cell culture. [PDF]

Bioresour Bioprocess
Liu Y, Gu Q, Liu Y, Xu G, Zhuang Y, Guo M, Li C.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source