Results 41 to 50 of about 4,393,221 (308)

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Physiological and Agronomical Responses of ‘Vairo’ Almond and ‘Big Top’ Nectarine Cultivars Grafted onto Different Prunus Rootstocks and Grown under Semiarid Mediterranean Conditions

Agronomy, 2022
Two trials were conducted under Mediterranean conditions to monitor several physiological indicators before harvest (leaf chlorophyll concentration, quantum yield of photosystem II electron transport, stem water potential, and stomatal conductance) and ...
Gemma Reig, Ignasi Iglesias, Lourdes Zazurca, Laura Torguet, Guillem Martinez, Xavier Miarnau   +5 more
doaj   +1 more source

A scan processor as an aid to program documentation [PDF]

, 1970
Program documentation was separated into two catagories: documentation for program use and documentation for program analysis, modification, or extension.
Oliver, P.
core   +1 more source

Productive Cluster Programming with OmpSs

, 2011
Peer ...
Bueno Hedo, Javier, Martinell Andreu, Luis, Duran González, Alejandro, Farreras Esclusa, Montserrat, Martorell Bofill, Xavier, Badia Sala, Rosa Maria, Ayguadé Parra, Eduard, Labarta Mancho, Jesús José   +7 more
openaire   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Proposed Livestock Research Program for Alaska [PDF]

, 1963
This report presents, primarily, areas of research and research goals on range management and beef cattle production that 1) appear to be most urgent and 2) that appear attainable within the next few years without a great expansion of personnel ...
Story, Charles D.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Implementing R and D policies : an analysis of Spain's pharmaceutical research program [PDF]

, 2003
Using detailed firm-level data, we analyze Spain's Pharmaceutical Research Program, and find differences between the ex ante announced evaluation criteria and their ex post implementation.
Desmet, Klaus, García, Clara Eugenia, Kujal, Praveen, Lobo, Félix   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source