Results 91 to 100 of about 381,564 (342)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Impact of Downtime on the Stability of the Production Schedule

Applied Sciences
Production scheduling is a fundamental element for the efficient control of material flow in production processes. Research work concerns the approaches, methods and tools used to optimize the loading of production resources with production orders ...
Piotr Kaźmierczak, Krzysztof Żywicki, Paulina Rewers   +2 more
doaj   +1 more source

A modified priority index for Günther's lot-sizing heuristic under capacitated single stage production [PDF]

Production Planning;Scheduling;produktieleer ...
Heuts, R.M.J., Selen, W.J.
core   +1 more source

Models and Algorithms for Production Planning and Scheduling in Foundries – Current State and Development Perspectives [PDF]

, 2012
Mathematical programming, constraint programming and computational intelligence techniques, presented in the literature in the field of operations research and production management, are generally inadequate for planning real-life production process ...
A. Stawowy, J. Duda
core  

Cooperation of Production, Product Handling and TransferScheduling for Semiconductor Fabrication [PDF]

, 2008
Various kind of productions are made in semiconductor fabrications, where it employs the production system with multiprocesses and multiple Automated Guided Vehicles(AGVs) for transportation.
Imai, Jun, Konishi, Masami, Ryohei, Hamana   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Extending Monitoring Area of Production Plant Using Synchronized Relay Node Message Scheduling

, 2022
Doan Perdana, Favian Dewanta, Ig. Prasetya Dwi Wibawa   +2 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

PRODUCTION SCHEDULES OF PREPARATION OF FODDER ADDITIVES FOR HIGHLY PRODUCTIVE ANIMALS IN THE CONDITIONS OF ECONOMY

, 2021
Olga Makarova, Vladimir Aleksandrovich, Sergey Nikolaevich, V.M. Makarov, Sergey Nikolaevich, Valentin Makarov, Alekseevich, ;, Yu Prytkov   +8 more
openalex   +1 more source

Solving two production scheduling problems with sequence-dependent set-up times [PDF]

In today s competitive markets, the importance of good scheduling strategies in manufacturing companies lead to the need of developing efficient methods to solve complex scheduling problems.
Helena Ramalhinho-Lourenço, Joao António Noivo   +1 more
core