Results 91 to 100 of about 6,566,838 (299)

Real-Time Production Scheduling and Industrial Sonar and Their Application in Autonomous Mobile Robots

open access: yesApplied Sciences
In real-time production planning, there are exceptional events that can cause problems and deviations in the production schedule. These circumstances can be solved with real-time production planning, which is able to quickly reschedule the operations at ...
Francisco Burillo   +4 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Programación óptima de la producción en una pequeña empresa de calzado – en Colombia / Optimal production scheduling in a small shoe business in Colombia

open access: yesRevista Científica de Ingeniería Industrial, 2014
RESUMEN El propósito de esta investigación fue diseñar la programación óptima de la producción en una pequeña empresa de calzado ubicada en la ciudad de San José de Cúcuta (Colombia), donde se identificaron las restricciones del sistema productivo ...
Viviana Karolina Ortiz-Triana
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Um modelo de otimização inteira mista e heurísticas relax and fix para a programação da produção de fábricas de refrigerantes de pequeno porte A mixed integer programming model and relax and fix heuristics for the production scheduling of small scale soft drink plants

open access: yesProduction, 2008
Neste artigo propomos um modelo de otimização inteira mista para o problema de dimensionamento e seqüenciamento dos lotes de produção em fábricas de refrigerantes de pequeno porte, com tempos e custos de set up de produção dependentes do seqüenciamento ...
Deisemara Ferreira   +2 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

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