Results 61 to 70 of about 6,566,838 (299)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Using a Genetic Algorithm, Integrated Preventive Maintenance Planning and Production Scheduling for a Single Machine [PDF]
, 2021 openalex +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
OPSI, 2020 Bogasari is one of the largest wheat flour companies in Indonesia, besides wheat flour also produces a byproduct namely pasta, pellet, and livestock food.
Purwati Purwati, Santika Sari
doaj +1 more source
Automated Design of Production Scheduling Heuristics: A Review
IEEE Transactions on Evolutionary Computation, 2016 Hyper-heuristics have recently emerged as a powerful approach to automate the design of heuristics for a number of different problems. Production scheduling is a particularly popular application area for which a number of different hyper-heuristics have ...
J. Branke +3 more
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Assembly and Production Line Designing, Balancing and Scheduling with Inaccurate Data: A Survey and Perspectives [PDF]
, 2023 Yuri N. Sotskov
openalex +1 more source
Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes
FEBS Letters, EarlyView.The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji +3 more
wiley +1 more source
People-Centric Evolutionary System for Dynamic Production Scheduling
IEEE Transactions on Cybernetics, 2019 Evolving production scheduling heuristics is a challenging task because of the dynamic and complex production environments and the interdependency of multiple scheduling decisions.
Su Nguyen +3 more
semanticscholar +1 more source