Results 131 to 140 of about 1,776,568 (282)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Economic Education Analysis Journal, 2013 Kesiapan kerja dipengaruhi oleh adanya pelatihan yaitu dengan dilaksanakannya praktik kerja industri dan prestasi akademik mata diklat produktif akuntansi.
Eka Evi Muktiani
doaj
Ethics-Rorty-cultural studies : towards an understanding of the cultural production of solidarity : a thesis presented in partial fulfillment of the requirements for the degree of Master of Arts in English at Massey University, Palmerston North, New Zealand [PDF]
, 2000 Is cultural studies on the verge of an ethical turn? What role could the work of Richard Rorty play in such an ethical turn? Rorty may be considered as a cultural theorist whose work enables a productive articulation of cultural studies and that area of ...
Hunt, Alistair Peter
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Hierarchical Organization and Inequality in an Economy with an Implicit Market for Productive Time [PDF]
This paper proposes an equilibrium theory of the organization of work in an economy with an implicit market for productive time. In this economy, agents have limited productive time and can choose to produce in autarky, buy productive time from helpers ...
Candelon, Bertrand, Dupuy, Arnaud
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Shirking or Productive Schmoozing: Wages and the Allocation of Time at Work [PDF]
Major strands of recent macroeconomic theory hinge on the relation of workers' efforts to their wages, but there has been no direct general evidence on this relation.
Daniel S. Hamermesh
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source