Results 171 to 180 of about 202,127,633 (309)

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

open access: yesAdvanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen   +9 more
wiley   +1 more source

Editorial: Signaling in roots: the brain of the plant. [PDF]

open access: yesFront Plant Sci
Panigrahy M   +2 more
europepmc   +1 more source

Ultrathin 2D In2O3 Nanosheets Confining Cu Single Atoms Synergized With Oxygen Vacancies for High Selectivity of Photocatalytic Reduction of CO2 to CO

open access: yesAdvanced Science, EarlyView.
In this work, we constructed an ultrathin two‐dimensional (2D) In2O3 nanosheet (In2O3‐Ns) structure based on oxygen vacancies (OV)‐rich defects and low crystallinity to anchor Cu single atoms (Cu SAs) and synthesized Cu/In2O3‐Ns photocatalysts. ABSTRACT In this work, we constructed an ultrathin two‐dimensional (2D) In2O3 nanosheet (In2O3‐Ns) structure ...
Yueying Yang   +10 more
wiley   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

open access: yesAdvanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko   +8 more
wiley   +1 more source

Regulation for Australia's federation in the 21st century

open access: yes, 2006
This is the text of a speech by the chair of the Productivity Commission, who also chairs the Regulation Taskforce, at the 2006 Australian Social and Economic Outlook Conference.
Productivity Commission
core  

Beyond Mycorrhizae: A Multi-Kingdom Community in Epiphytic Orchid Roots Reveals Cyanobacteria Intracellular and a Velamen Microbial Refuge. [PDF]

open access: yesEnviron Microbiol Rep
de Medeiros Oliveira E   +6 more
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

open access: yesAdvanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang   +17 more
wiley   +1 more source

Unveiling diverse interactions between soil microbiota and host plants for sustainable agriculture: current limitations and prospects. [PDF]

open access: yesFront Microbiol
Batool M   +9 more
europepmc   +1 more source

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