Results 101 to 110 of about 2,178 (240)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Vínculo público-privado como estrategia para el fortalecimiento del pequeño productor:

open access: yesPensamiento y Acción Interdisciplinaria, 2017
Tradicionalmente, han sido los sectores público y privado quienes han realizado acciones en beneficio de una de las actividades económicas más importantes de Chile, la agricultura.
Betsabé Rubilar Arriaza
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

TRÍADAS PUTUMAYENSES: RELACIONES PATRÓN-CLIENTE en la economía de la cocaína

open access: yesRevista Colombiana de Antropología, 2006
ESTE TEXTO ANALIZA LAS RELACIONES DE PRODUCCIÓN DE COCA EN EL BAJO PUTUMAYO (Colombia) como relaciones de patrón-cliente. El artículo sostiene que el intercambio de muestras tangibles de buena voluntad entre los intermediarios, por muestras intangibles ...
OSCAR JANSSON
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Diseño, sistema productor de sentido

open access: yesKepes, 2005
El diseño, pieza fundamental en los sistemas de producción, ha variado el rumbo hacia una nueva designación de sus productos, superando la proyectación objetual, introduciendo estrategias que impacten positivamente los sustratos culturales, reconociendo
Gustavo Villa Carmona
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Los nombres del productor

open access: yes, 2009
Comunicaciones del II Congreso Internacional sobre Análisis Fílmico. Universidad Complutense de Madrid, Madrid junio de 2009.
openaire   +1 more source

¿Agricultor familiar… pequeño productor?

open access: yes, 2016
Facultad de Ciencias Agrarias y ...
Fontana, Paula Andrea, Dumrauf, Sergio
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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