Results 221 to 230 of about 1,166,419 (314)

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Hepatitis A and B immunity and vaccination willingness among special school employees in Rhineland-Palatinate. [PDF]

Front Public Health
Kegel P, Gössler F, Schmitz N, Dietz P, Letzel S, Diehl E.   +5 more
europepmc   +1 more source

Metal‐Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels‐Bridged Intracranial‐Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression

Advanced Science, EarlyView.
A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Chenxi Zhang, Zhongsheng Xu, Xiaowen Xu, Zening Zhang, Ranran Luo, Pengchen Ren, Yingying Luo, Qiuchi Wu, Xinyu Liu, Guodong Liu, Xiaojing He, Yun Liu   +11 more
wiley   +1 more source

The relationship between inclusive leadership in sustainable education and teachers' subjective wellbeing in Türkiye: the mediating role of affective commitment. [PDF]

Front Psychol
Çevik MN.
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Effects of a brief health education video on employees' mental health help-seeking in small and medium-sized enterprises: A randomized controlled trial. [PDF]

J Family Med Prim Care
Fukita S, Kawasaki H.
europepmc   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

Advanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen, Xiaoni Gao, Shuai Lu, Yi Zhang, Xing Zheng, Matthaios Santamouris   +5 more
wiley   +1 more source

Job crafting and teachers' well-being: a case of private school teachers. [PDF]

BMC Public Health
Aslam A, Kamran M, Siddiqui S.
europepmc   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Human Skin‐Inspired Flexible Pressure Sensor with Multi‐Modulus Porous Structure

Advanced Electronic Materials, EarlyView.
Skin‐inspired dual‐modulus pressure sensor is developed by mimicking epidermis–dermis mechanics with a porous MWCNT/PDMS composite, achieving high sensitivity and wide linear range through simple fabrication, and enabling scalable, cost‐effective applications in wearable electronics, robotics, and human–machine interfaces.
Hyeongmin Park, Jinsung Kim, Minwoo Kim, Changhyun Noh, Sumin Myoung, Hyeona Lim, Jaehee Han, Chulhwan Park, Chungryong Choi, Eunho Lee, Sungjun Park, Daegun Kim, Giwon Lee   +12 more
wiley   +1 more source