Results 181 to 190 of about 3,128,948 (238)

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

open access: yesAdvanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin   +21 more
wiley   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

open access: yesAdvanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect

open access: yesAdvanced Science, EarlyView.
Due to the synergistic effect of ENernst,H2O2${E}_{\mathrm{Nernst},\ {\mathrm{H}}_{2}{\mathrm{O}}_{2}}$ and ENernst,H+${E}_{\mathrm{Nernst},\ {\mathrm{H}}^{+}}$, the proposed sensors in this study can achieve ultralow H2O2 detection limit as low as 1.8 × 10−12 M based on the stacked PEDOT: BTB/PEDOT: PSS semiconducting layer.
Zhaoqun Wang   +12 more
wiley   +1 more source

A Porphyrin Nanomaterial for Photoimmunotherapy for Treatment of Melanoma

open access: yesAdvanced Science, EarlyView.
The TPC@OVA NPs are developed as dual‐functional nanomaterials combining phototherapy and immunotherapy for melanoma treatment. This system effectively ablates primary tumors, induces immunogenic cell death, promotes dendritic cell maturation, and enhances T cell activation.
Zhuang Fan   +6 more
wiley   +1 more source

In Situ Control of Reactive Mesogens Alignment During 3D Printing by Two‐Photon Lithography

open access: yesAdvanced Science, EarlyView.
Manipulating material properties at the microscale is crucial for 3D printing of smart microdevices. Two‐photon lithography directly patterns molecular alignment in liquid crystal resists. The polymerization reaction wavefront along the writing path induces an easy‐axis for the mesogenic moieties.
Tiziana Ritacco   +4 more
wiley   +1 more source

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