Results 141 to 150 of about 4,421 (236)

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Paediatric urolithiasis: Medical & surgical management & sophistication. [PDF]

World J Clin Pediatr
Jain S, Jain PK.
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Piloting an Interpretive External Quality Assurance Model for Genomic Testing for Childhood Syndromes and Intellectual Disability. [PDF]

J Mol Diagn
Lundie B, Chai SY, Byrne AB, Azmanov D, Christodoulou J, Haas MA, Kassahn KS, Lunke S, Stott A, Thompson BA, Badrick T, Bennetts B.   +11 more
europepmc   +1 more source

Thermal Spin Coated PbS QD SWIR Imager for Non‐Invasive Glucose Monitoring

Advanced Science, EarlyView.
Thermal spin‐coating enables controlled film formation of PbS quantum dots, leading to denser packing, reduced defect‐assisted transport, and improved carrier extraction. The resulting photodetectors exhibit suppressed dark current, enhanced responsivity, and faster response.
Lei Rao, Shuo Cheng, Qian Chen, Jiankai Wang, Jingrui Ma, Junjie Hao, Xiao Wei Sun, Wei Chen, Cun Zheng Ning, Haodong Tang   +9 more
wiley   +1 more source

Protecting Minors From Medical Malpractice Act: Implications for Otolaryngology-Head & Neck Surgery. [PDF]

Laryngoscope
Sharma S, McKenna MK, Ongkasuwan J, Brenner MJ.   +3 more
europepmc   +1 more source

Femtosecond‐Laser‐Induced Physical Unclonable Random Maze Structure for Storage‐Free Encryption

Advanced Science, EarlyView.
Femtosecond‐laser‐induced gold random maze structures serve as multimodal physical unclonable functions for storage‐free encryption. Their stochastic optical, electrical, and Raman responses are generated by plasmon‐assisted Marangoni formation and converted into AES‐compatible keys without permanent secret‐key storage, offering a portable route toward
Shiru Jiang, Hongliang Li, Shengjie Ma, Sang‐Shin Lee, Lei Wang, Mengyun Hu, Heping Zeng   +6 more
wiley   +1 more source

Learning planetary health through international & interprofessional education: a qualitative study of student reflections. [PDF]

Med Educ Online
Park H, Kim SH, Kong AP, Leech M, De Ponti F, Fischer M, Bustos I, Vonderhagen W, Lee YM.   +8 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Exploring the perspectives of antimicrobial stewardship pharmacists in England on the subscription model for antimicrobial drugs. [PDF]

JAC Antimicrob Resist
Hughes S, Baltas I, Gilchrist M.
europepmc   +1 more source