Results 81 to 90 of about 518,707 (267)
Advanced Science, EarlyView.CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang +17 more
wiley +1 more source
On Architectural Practice and Arithmetic Abilities in Renaissance Italy
Architectural Histories, 2015 The article examines the figure of the architect at work in Renaissance Italy, when a major change occurred in the practice of design with the spread of arithmetic. This deep scientific, technical, methodological, and cultural shift involved the image of
Giulia Ceriani Sebregondi
doaj +3 more sources
Educating the global citizen in sustainable development: the influence of accreditation bodies on professional programmes [PDF]
, 2011 It is estimated that over 50% of UK CO2 emissions arise from the buildings and industry sector. Globally construction is estimated to be the world’s largest employer with 111 million employees. The Built Environment sector is therefore a major economic
Beacock, Peter +2 more
core
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Droplet Digital CRISPR for Nucleic Acid Detection
Advanced Science, EarlyView.This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang +4 more
wiley +1 more source
Designing the interface between research, learning and teaching. [PDF]
, 2007 : This paper’s central argument is that teaching and research need to be reshaped so that they connect in a productive way. This will require actions at a whole range of levels, from the individual teacher to the national system and include the ...
Drew, Linda
core
Enhanced Management of Personal Astronomical Data with FITSManager
, 2011 Although the roles of data centers and computing centers are becoming more and more important, and on-line research is becoming the mainstream for astronomy, individual research based on locally hosted data is still very common.
Ajit Kembhavi +13 more
core +1 more source
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models
Advanced Science, EarlyView.His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li +13 more
wiley +1 more source
Shifting Core and Slipping Foundation: An Uncertain Future of Landscape Architecture in European Universities [PDF]
, 2010 Faced with the dual and often conflicting necessity to be scientific and design practices the discipline of landscape architecture today is challenged to re-examine its core and intellectual foundation.
Koh, J.
core +1 more source