Results 191 to 200 of about 259,559 (262)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Public Perceptions of Ethical and Professional Practice in Jordanian Community Pharmacies: A Cross-Sectional Study. [PDF]

Patient Prefer Adherence
Jarad OF, Hasan HE, Khabour OF, Alzoubi KH, Al-Delaimy WK.   +4 more
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Impact of a booster intervention of the 'More Time at Patients' Side' programme on patients and healthcare professionals in a Swiss hospital: protocol for a cluster randomised controlled trial. [PDF]

BMJ Open
Buclin CP, Bürgisser N, Mongin D, Le Mauguen A, Farhoumand PD, Berner A, Daverio JE, Barrios J, Reny JL, Courvoisier DS, Agoritsas T.   +10 more
europepmc   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

The Evidence Behind ANCC's Pathway to Excellence® Credential's Return on Investment. [PDF]

J Nurs Adm
Swartwout E.
europepmc   +1 more source

Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity

Advanced Science, EarlyView.
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini, Claudia Alvarez‐Martin, Paula Angermair‐Barkai, Olivier Penacchio, Marc Paz, Matthew Pelowski, Dan Dediu, Antoni Rodriguez‐Fornells, Xim Cerda‐Company   +8 more
wiley   +1 more source

The corporate takeover of Alzheimer's treatment: a crisis in neurological autonomy? [PDF]

Arq Neuropsiquiatr
Araujo AQC.
europepmc   +1 more source

Observation of practical teaching skills instrument (OPTIn): transforming the way we observe, evaluate and improve physically active teaching strategies. [PDF]

Front Sports Act Living
Lander N, Patterson K, Eather N, Robinson K, Riley N, Lai SK, Weatherell N, Orr J, Salmon J.   +8 more
europepmc   +1 more source

Accelerating Quality Midwifery Education: Identifying Educators’ Professional Development Needs

Berg F, Erlandsson K, Pappu NI, Kemp J, Raha P, Wigert H, Basri R, Bogren M.   +7 more
europepmc   +1 more source