Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Professional values, ageism, attitudes and willingness towards geriatric care among nursing students in China: a multiple path analysis. [PDF]
Pang R, Liu F, Li T.
europepmc +1 more source
Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang +8 more
wiley +1 more source
Understanding the relationship between professional values and caring behavior among nurses in intensive care units: a cross-sectional study from Palestine. [PDF]
Ejheisheh MA +7 more
europepmc +1 more source
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu +9 more
wiley +1 more source
The relationship between moral reasoning and nurses' professional values in undergraduate nursing students: a descriptive-correlational study. [PDF]
Nazari AM +4 more
europepmc +1 more source
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss +9 more
wiley +1 more source
Professional values at the beginning of medical school: a quasi-experimental study. [PDF]
Vilagra S +7 more
europepmc +1 more source
Shaping professional identity in dentistry: a cross-sectional study of value prioritization among undergraduate students [PDF]
Ebtihaj T. Nafea +3 more
openalex +1 more source

