Results 111 to 120 of about 37,054 (216)

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

الاكتئاب لدى النساء Editor of ArabiXiv assistant Professor associate Professor Professor associate Professor Professor

يعد الاكتئاب، بمختلف أنواعه، من أكثر الاضطرابات النفسية انتشاراً وشدة، ومن أعراضه افتقاد المكتئبين لمعنى الحياة وتعكر مزاجهم والشعور باليأس والتعاسة والمعاناة والأرق وفقدان الأمل بالحياة من كل شيء، وقد ينتهي الاكتئاب بالانتحار في كثير من الحالات (15% وفقاً لبعض الدراسات والإحصائيات).
Khaled Moustafa, Samer Rudwan
openaire   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

علاج القبول والالتزام:1 assistant Professor associate Professor Professor associate Professor Professor

ينتمي علاج القبول والالتزام إلى "الموجة الثالثة" للعلاج السلوكي. ويقصد "بالموجة الثالثة" أن العلاج السلوكي يقترب هنا من الظواهر المعقدة جداً للسلوك الإنساني، التي كان من الصعب الوصول إليها حتى الآن من خلال مبادئ الإشراط الإجرائي ومفهوم التمثل الاستعرافي للمعلومات. ومن بين هذه الظواهر المعقدة الوعي، والقبول والقيم الشخصية والروحانية.
openaire   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

The Professor Is In

The Canadian Journal of Hospital Pharmacy, 2009
openaire   +3 more sources

الفصام: أسبابه وعلاجه Editor of ArabiXiv assistant Professor associate Professor Professor associate Professor Professor

يعني مفهوم الفصام "انقسام العقل أو الشخصية" حيث يشعر المريض وكأن ذاته وأحاسيسه وإدركاته منقسمة. وهو من الأمراض التي تصنف ضمن طائفة الذهانات داخلية المنشأ، أي الذهانات التي لا تزال أسباب ظهورها غامضة. وهذا الاضطراب يعيق الوظائف الأساسية التي تمنح الإنسان السوي مشاعر الفردية والخصوصية وحرية الاختيار، وغالباً ما يعتقد الفصامي أن أفكاره ومشاعره العميقة ...
Khaled Moustafa, Samer Rudwan
openaire   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Apresentação

Convergência Lusíada, 2017
O número 28 da revista Convergência Lusíada apresenta ao leitor um conjunto heterogêneo de textos sobre autores de diferentes épocas e gêneros, de autoria de pesquisadores brasileiros e portugueses. [...]
Madalena Vaz Pinto
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