Results 151 to 160 of about 37,054 (216)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Nível de atividade física dos pais em relação ao Índice de Massa Corporal dos filhos, na escola fundação Bradesco, na cidade Cacoal/RO

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2012
Maria Silvina Silva Costa, Vera Lúcia Tavares Moreira, Simone de Oliveira, Weliton Nunes Soares, Kleber Farinazzo Borges, Rafael Ayres Romanholo   +5 more
doaj  

Efeitos fisiológicos do exercício físico combinado com a oclusão vascular parcial: revisão sistemática

Revista Brasileira de Prescrição e Fisiologia do Exercício, 2022
João Gabriel Souza Cesar, Vania Cristina dos Reis Miranda, Keyleytonn Sthil Ribeiro, Elaine Cristina Martinez Teodoro   +3 more
doaj  

نظرية الإرادة في التربية الصحية assistant Professor associate Professor Professor associate Professor Professor

تهدف التربية الصحية إلى دفع الناس من جميع الاعمار إلى تحمل المسؤولية فيما يتعلق بصحتهم الشخصية. وبهذا فإن الهدف يتمثل في التحلل من انماط السلوك الخطر وبناء انماط سلوك صحي بما في ذلك الاحتفاظ بأنماط السلوك التي تم اكتسابها والتي هي داعمة للصحة. وتتميز هذه العملية بصعوبات كثيرة ولا تحقق على ما يبدو، لدى المعنيين، النجاح المرغوب. فقد ظهر أن كثيرا من انماط
openaire   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

السلوك الصحي والاتجاهات نحو الصحة assistant Professor associate Professor Professor associate Professor Professor

هدفت هذه الدراسة إلى تحليل السلوك الصحي والاتجاهات الصحية للطّلاب من منظور عبر ثقافي بهدف إيجاد فروق عبر ثقافية بين عينةِ سوريةِ وألمانيةِ. استخدم في الدراسة استبيان السلوك الصحي ، (Steptoe, 1991) الذي يقيس مظاهر معينة من السلوك الصحي والاتجاهات نحوه. اشتملت عينة الدراسة على 300 مفحوص كان بينهم 201 أنثى (67%) و 99 ذكر (33%).
openaire   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Sharing and Stealing Professor of Law Professor of Law Assistant Professor/Associate Professor

The purpose of copyright is to encourage the creation and mass dissemination of a wide variety of works. Until recently, most means of mass dissemination required a significant capital investment. The lion's share of the economic proceeds of copyrights were therefore channeled to publishers and distributors, and the law was designed to facilitate that.
openaire   +1 more source

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

Advanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato, Jesús A. Andrés‐San Román, Juan Garrido‐García, Carmen Gordillo‐Vázquez, Ana M. Palacios, Elisabeth Lidueña‐Fernández, Katie McDole, Pedro Gómez‐Gálvez, Valentina Annese, Luis M. Escudero   +9 more
wiley   +1 more source