Results 171 to 180 of about 388,853 (307)
يعني مفهوم الفصام "انقسام العقل أو الشخصية" حيث يشعر المريض وكأن ذاته وأحاسيسه وإدركاته منقسمة. وهو من الأمراض التي تصنف ضمن طائفة الذهانات داخلية المنشأ، أي الذهانات التي لا تزال أسباب ظهورها غامضة. وهذا الاضطراب يعيق الوظائف الأساسية التي تمنح الإنسان السوي مشاعر الفردية والخصوصية وحرية الاختيار، وغالباً ما يعتقد الفصامي أن أفكاره ومشاعره العميقة ...
Khaled Moustafa, Samer Rudwan
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Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Convergência Lusíada, 2017 O número 28 da revista Convergência Lusíada apresenta ao leitor um conjunto heterogêneo de textos sobre autores de diferentes épocas e gêneros, de autoria de pesquisadores brasileiros e portugueses. [...]
Madalena Vaz Pinto
doaj
Sequential sampling models have provided accurate accounts of people’s choice, response time, and preference strength in value-based decision-making tasks. Conventionally, these models are developed as Markov-type processes (such as random walks or diffusion processes) following the Kolmogorov axioms.
Gunnar Epping +3 more
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Advanced Science, EarlyView.Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan +16 more
wiley +1 more source
Adolfo Lima e a Introdução do Teatro Escolar Educativo em Portugal
Revista Portuguesa de Educação Artística, 2014 Embora as representações teatrais em estabelecimentos escolares nunca tenham definitivamente acabado, é com a revolução pedagógica iniciada pelo Movimento da Escola Nova que as atividades dramáticas, e as artes em geral, voltam a granjear, desde a Grécia
António Silva
doaj
Advanced Science, EarlyView.As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia +13 more
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يعتبر مفهوم الذات مركب مركزي لشخصية التلميذ. وعلى خلفية مسلمة القدرة على الإدراك الانعكاسي وتقويم أطر الشخص-المحيط، فإننا ننطلق من أن الإنسان لا يطور "صورة" عن محيطه فحسب وإنما عن ذاته. وتعد هذه "الصورة الذاتية" في البحث النفسي الإمبيريقي الجديد تمثيلاً معرفياً داخلياً للمعرفة حول الإنسان لنفسه والقناعات المتضمنة في ذلك. بالإضافة إلى ذلك يوجد اتفاق تام
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Advanced Science, EarlyView.Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li +11 more
wiley +1 more source