Results 251 to 260 of about 388,853 (307)

Beyond Classical Reward Circuits: Dorsal Striatum Proteomic Alterations in an Adolescent Phencyclidine-Induced Mouse Model of Schizophrenia and Nicotine Use. [PDF]

Int J Mol Sci
Souza TP, Rodríguez-Vega A, Dutra-Tavares AC, Semeão KA, Filgueiras CC, Ribeiro-Carvalho A, Manhães AC, Abreu-Villaça Y.   +7 more
europepmc   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

Organizational and pedagogical characterization of vocational training in nursing in the Federal Education Network. [PDF]

Rev Bras Enferm
Jesus LA, Silva GTRD, Vieira SL, Backes VMS.   +3 more
europepmc   +1 more source

Interfacial Reconstruction Enables Enhanced Thermoelectric Performance in Bismuth Telluride‐Based Alloys

Advanced Science, EarlyView.
Bismuth telluride‐based alloys are benchmark thermoelectric materials for near‐room‐temperature applications. Here, SnSe‐induced interfacial reconstruction simultaneously optimizes carrier and phonon transport in Bi0.4Sb1.6Te3, achieving a peak ZT of ∼1.38 at 363 K and a device efficiency of ∼6.47%, providing an effective strategy for high‐performance ...
Wenyi Chen, Xiao‐Lei Shi, Meng Li, Chao Zhang, Konstantin Faershteyn, Siqi Liu, Yongqi Chen, Chengjiong He, Wanyu Lyu, Jun Pei, Nanhai Li, Zhi‐Gang Chen   +11 more
wiley   +1 more source

[From New York to Rio de Janeiro: a book's trip, 1925]. [PDF]

Hist Cienc Saude Manguinhos
Rocha HHP.
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Health promotion strategies for adolescents with suicidal behavior: a scoping review. [PDF]

Rev Esc Enferm USP
Bezerra EADAC, Heidemann ITSB, Souza AA, Fonseca ERD, Coelho CT, Daza PMO, Beckert RAT, Ferreira AA.   +7 more
europepmc   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

The accuracy of a smartphone-based hearing assessment compared to conventional audiometry in workers exposed to noise according to sociodemographic, occupational and pre-assessment conditions. [PDF]

Codas
Lima CMS, Fernandes LCR, Corona AP.
europepmc   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source