Results 211 to 220 of about 312,430 (306)

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Nível de atividade física dos pais em relação ao Índice de Massa Corporal dos filhos, na escola fundação Bradesco, na cidade Cacoal/RO

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2012
Maria Silvina Silva Costa, Vera Lúcia Tavares Moreira, Simone de Oliveira, Weliton Nunes Soares, Kleber Farinazzo Borges, Rafael Ayres Romanholo   +5 more
doaj  

Vascular surgery core curriculum for medical degrees in Brazil: a proposal. [PDF]

J Vasc Bras
Shiomi AY, de Souza JM, de Andrade DP, Marques MA.   +3 more
europepmc   +1 more source

السلوك الصحي والاتجاهات نحو الصحة assistant Professor associate Professor Professor associate Professor Professor

هدفت هذه الدراسة إلى تحليل السلوك الصحي والاتجاهات الصحية للطّلاب من منظور عبر ثقافي بهدف إيجاد فروق عبر ثقافية بين عينةِ سوريةِ وألمانيةِ. استخدم في الدراسة استبيان السلوك الصحي ، (Steptoe, 1991) الذي يقيس مظاهر معينة من السلوك الصحي والاتجاهات نحوه. اشتملت عينة الدراسة على 300 مفحوص كان بينهم 201 أنثى (67%) و 99 ذكر (33%).
openaire   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

[Autism spectrum disorder today: critical reflections on hyperdiagnosis]. [PDF]

Cad Saude Publica
Silva RAD, Queiroz SDPO, Silva FPD.
europepmc   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Adsorption of water on pristine graphene: a van der Waals density functional study with the vdW-C09 approach. [PDF]

J Mol Model
Santos AO, Mendonça BHS, de Moraes EE.
europepmc   +1 more source

Sharing and Stealing Professor of Law Professor of Law Assistant Professor/Associate Professor

The purpose of copyright is to encourage the creation and mass dissemination of a wide variety of works. Until recently, most means of mass dissemination required a significant capital investment. The lion's share of the economic proceeds of copyrights were therefore channeled to publishers and distributors, and the law was designed to facilitate that.
openaire   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source