Results 231 to 240 of about 375,598 (307)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Adsorption of water on pristine graphene: a van der Waals density functional study with the vdW-C09 approach. [PDF]

J Mol Model
Santos AO, Mendonça BHS, de Moraes EE.
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Índice de pressão arterial e obesidade em escolares de etnias brancas e negras de 7 a 12 anos dos ensinos públicos e privados do município de Cacoal - RO

Revista Brasileira de Prescrição e Fisiologia do Exercício, 2011
Rafael Ayres Romanholo, Kleber Borges Farinazzo, Mario Sergio Vaz Silva, Weliton Nunes   +3 more
doaj  

Binge drinking profile and sleep duration among Panamanian college professors and administrative workers. [PDF]

Rev Bras Med Trab
Iribarren-Llorente LL, Caballero LGR, Mendoza NPV, Vásquez LDCG, López ALM.   +4 more
europepmc   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Lifestyle changes after retirement: a Grounded Theory. [PDF]

Rev Bras Enferm
Marcon SS, Marquete VF, Silva TPD, Barreto MDS, Haddad MDCFL, Loureiro HMAM, Logullo VV, Ichisato SMT.   +7 more
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Health promotion strategies for adolescents with suicidal behavior: a scoping review. [PDF]

Rev Esc Enferm USP
Bezerra EADAC, Heidemann ITSB, Souza AA, Fonseca ERD, Coelho CT, Daza PMO, Beckert RAT, Ferreira AA.   +7 more
europepmc   +1 more source

A Physical Adaptive Material Motor Unit Neural Network: A Hygromorph Composite Material Machine

Advanced Science, EarlyView.
This study introduces a new class of material‐based intelligent machines. It presents a Physical Adaptive Material Motor Unit Neural Network, an assembly of smart 4D printed actuators and a controlling system that adapt through environmental interaction its shading behavior.
Charles de Kergariou, Helmut Hauser, David Correa   +2 more
wiley   +1 more source