Results 61 to 70 of about 375,498 (307)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Professores(as): trabalho, vida e saúde [PDF]

open access: yes, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Programa de Pós-Graduação em Educação.Neste estudo - que combina a abordagem qualitativa e quantitativa - analisa-se a relação entre o trabalho docente e a ...
Zacchi, Marlucy Silveira de Souza
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Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang   +13 more
wiley   +1 more source

Oficina de repertório musical para professores [PDF]

open access: yes, 2014
Trabalho apresentado no 31º SEURS - Seminário de Extensão Universitária da Região Sul, realizado em Florianópolis, SC, no período de 04 a 07 de agosto de 2013 - Universidade Federal de Santa Catarina.Este relato de experiência refere-se ao trabalho do ...
Hirsch, Isabel   +4 more
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The Impact of Anger Control and Zero Violence Training on Preventing Teacher Violence: A Quantitative Study from Timor-Leste

open access: yesInternational Journal of Contemporary Educational Research
This study examines the impact of anger control and zero-violence training on the prevention of violent teaching among elementary school teachers in Timor-Leste, which can have implications for the professionalism of teachers and the safety of schools ...
Salvador Magno Ximenes   +2 more
doaj   +1 more source

EFEITO DO PREBIÓTICO E DO ÁCIDO BUTÍRICO IN OVO SOBRE O DESEMPENHO, DIGESTIBILDADE DOS NUTRIENTES DA RAÇÃO E BIOMETRIA DO TRATO GASTRINTESTINAL DE PINTOS SUBMETIDOS AO JEJUM

open access: yesCiência Animal Brasileira, 2010
Desenvolveram-se dois experimentos para avaliar o desempenho, a digestibilidade de nutrientes da ração e a biometria de órgãos do trato gastrintestinal de pintos, oriundos de ovos inoculados com prebiótico ou ácido orgânico, submetidos a jejum hídrico e ...
Nadja Susana Mogyca Leandro   +5 more
doaj   +1 more source

Scientific literacy and STS approach in the view of biological science undergraduate students: a focal group analysis

open access: yesInvestigações em Ensino de Ciências, 2020
In this work we present a qualitative research, in which we used the technique of focal group to investigate the views of biological science undergraduate students about Science, Technology, Society and their interrelations in order to understand their ...
Filipe Lima Malta   +2 more
doaj   +1 more source

Triangular Index Ratio as an Alternative Method to the Alpha Angle for Defining the Presence of Cam Morphology: A Prospective Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Cam morphology, which is a significant risk factor for hip osteoarthritis, is commonly quantified by the alpha angle (AA). This study aims to explore the potential of the triangular index ratio (TIR) to quantify cam morphology on anteroposterior radiographs by assessing the association between TIR‐defined cam morphology and the development of
Jinchi Tang   +7 more
wiley   +1 more source

Certificação de professores: contradições de uma política [PDF]

open access: yes, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação, Programa de Pós-graduação em Educação, Florianópolis, 2009Nesta pesquisa procuro analisar a política de certificação de professores e suas implicações sobre
Schneider, Mara Cristina
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