Results 171 to 180 of about 375,598 (307)

Educational spaces for teacher training in nursing at the Unified Health System Vocational Schools. [PDF]

open access: yesRev Bras Enferm
Ribeiro-Barbosa JC   +4 more
europepmc   +1 more source

الهجرة من منظور نفسي assistant Professor associate Professor Professor associate Professor Professor

open access: yes
تؤدي الهجرة إلى تغييرات كبيرة في البنية النفسية والاجتماعية لأي مجتمع كان؛ إنها تؤثر على الطبقات الاجتماعية والاقتصادية، والسياسة، والثقافية، والنظام الصحي. كما أنها تؤثر على إدراك المهاجرين والسكان المحليين على حد سواء، الأمر الذي يؤثر بدوره على الهجرة.
openaire   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

open access: yesAdvanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao   +5 more
wiley   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

open access: yesAdvanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu   +12 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

open access: yesAdvanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu   +17 more
wiley   +1 more source

الخوف الذي كشف الغطاء assistant Professor associate Professor Professor associate Professor Professor

open access: yes
في أزمة كورنا انكشف حجم الهشاشة التي نحن فيها. لقد ولد فيض المعلومات الكثيرة والمتناقضة وضعف الإمكانات الفردية للسيطرة على الخطر مشاعر التهديد، وظهرت بالنتيجة تصرفات قد تبدو غير مفهومة، كهوس شراء ورق التواليت والتخزين والمبالغة في تصرفات وظيفتها توليد الإحساس الوهمي للسيطرة على خطر يحمل صفة التهديد الحقيقي، وفي الوقت نفسه فإن الفرد لا يملك الكثير من ...
openaire   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

open access: yesAdvanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin   +6 more
wiley   +1 more source

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