Results 221 to 230 of about 36,514 (265)

Exploiting Bulk Photovoltaic Effect in a Polar Hybrid Perovskite Towards Self‐Powered Detection of Weak Ultraviolet Polarized Light

open access: yesAdvanced Science, EarlyView.
Benefiting from intrinsic polarization, DJ‐type 2D perovskite crystals deliver self‐powered polarization‐resolved photocurrent under weak polarized UV light via the bulk photovoltaic effect, showing a high anisotropic factor of 8. ABSTRACT Weak light detection is essential for achieving high‐performance photodetectors with minimal power consumption ...
Xinyuan Zhang   +2 more
wiley   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

open access: yesAdvanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao   +6 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

open access: yesAdvanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng   +9 more
wiley   +1 more source

Knowing to care: life stories of adolescent survivors of suicide attempts in a Brazilian metropolis. [PDF]

open access: yesRev Esc Enferm USP
Martins LY   +4 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

open access: yesAdvanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang   +20 more
wiley   +1 more source

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