Results 211 to 220 of about 375,498 (307)

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

open access: yesAdvanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang   +5 more
wiley   +1 more source

الصورة السورية لمقياس بيك للاكتئاب assistant Professor associate Professor Professor associate Professor Professor

open access: yes
يتيح توفر أدوات القياس المقننة على البيئة المحلية والبيئات الأخرى إجراء تشخيص دقيق للاضطرابات النفسية و تنفيذ دراسات مسحية ومقارنة، وعلى الأخص فيما يتعلق بواحد من أكثر الاضطرابات النفسية شيوعاً، ألا وهو الاكتئاب. وقد هدفت هذه الدراسة إلى تقنين قائمة بيك للاكتئاب التي تعتبر واحدة من أكثر الأدوات انتشاراً واستخداماً في العالم.
openaire   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

open access: yesAdvanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li   +20 more
wiley   +1 more source

[Effect of an intervention in physical education classes on the reduction of sedentary behavior in adolescents]. [PDF]

open access: yesCad Saude Publica
Brito ALDS   +5 more
europepmc   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

open access: yesAdvanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang   +6 more
wiley   +1 more source

Nível de atividade física dos pais em relação ao Índice de Massa Corporal dos filhos, na escola fundação Bradesco, na cidade Cacoal/RO

open access: yesRevista Brasileira de Obesidade, Nutrição e Emagrecimento, 2012
Maria Silvina Silva Costa   +5 more
doaj  

Efeitos fisiológicos do exercício físico combinado com a oclusão vascular parcial: revisão sistemática

open access: yesRevista Brasileira de Prescrição e Fisiologia do Exercício, 2022
João Gabriel Souza Cesar   +3 more
doaj  

نظرية الإرادة في التربية الصحية assistant Professor associate Professor Professor associate Professor Professor

open access: yes
تهدف التربية الصحية إلى دفع الناس من جميع الاعمار إلى تحمل المسؤولية فيما يتعلق بصحتهم الشخصية. وبهذا فإن الهدف يتمثل في التحلل من انماط السلوك الخطر وبناء انماط سلوك صحي بما في ذلك الاحتفاظ بأنماط السلوك التي تم اكتسابها والتي هي داعمة للصحة. وتتميز هذه العملية بصعوبات كثيرة ولا تحقق على ما يبدو، لدى المعنيين، النجاح المرغوب. فقد ظهر أن كثيرا من انماط
openaire   +1 more source

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