Results 251 to 260 of about 1,723,437 (335)

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

[From New York to Rio de Janeiro: a book's trip, 1925]. [PDF]

Hist Cienc Saude Manguinhos
Rocha HHP.
europepmc   +1 more source

أهمية المعايير في إعداد وتأهيل المعلم assistant Professor associate Professor Professor associate Professor Professor

يعد ضمان جودة التأهيل والتعليم وإعداد المعلم واحدة من المهام الأساسية التي يفترض أن تحتل الأولوية القصوى في المؤسسات التربوية. وتشكل واحدة من التحديات الرئيسية التي تواجهها التربية في بدايات القرن الواحد وعشرين. ولعل إدخال المعايير standards واختبارها يعد واحداً من العناصر الأساسية في التعليم والتأهيل والإعداد من أجل ضمان نوعية عالية من التعليم ...
openaire   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Care strategies for children with tracheostomy at school: a scoping review. [PDF]

Rev Esc Enferm USP
Pessanha FB, Depianti JRB, Pimentel TGPP, Cabral IE.   +3 more
europepmc   +1 more source

The learning performance and behavior of school children during the COVID-19 pandemic school closures: from the perspectives of parents and teachers. [PDF]

Codas, 2023
Castro GM, Martins-Reis VO, Celeste LC.
europepmc   +1 more source

خفض الحساسية بحركات العين وإعادة المعالجة assistant Professor associate Professor Professor associate Professor Professor

تعد الأساليب الفعالة لعلاج الصدمات موضوع يحظى بأهمية متزايدة. ويمكننا في الوقت الراهن العثور بسرعة على ما تبحث عنه على الإنترنت، ولهذا فقد أثارت طريقة خفض الحساسية بحركات العين وإعادة المعالجة Eye movement desensitization and reprocessing والتي يرمز لها اختصاراً EMDR باهتمام المؤلفة، نظراً لتعدد التقارير التي تشير إلى أنه "علاج سريع وفعال للصدمات ...
openaire   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Efeitos fisiológicos do exercício físico combinado com a oclusão vascular parcial: revisão sistemática

Revista Brasileira de Prescrição e Fisiologia do Exercício, 2022
João Gabriel Souza Cesar, Vania Cristina dos Reis Miranda, Keyleytonn Sthil Ribeiro, Elaine Cristina Martinez Teodoro   +3 more
doaj  

Behavioral profile predicts ethanol preference in adolescent mice, but not in adults: A machine learning approach. [PDF]

Alcohol Clin Exp Res (Hoboken)
Portugal LCL, Gonçalves BDS, Fagundes EA, de Sá MFF, Filgueiras CC, Dutra-Tavares AC, Manhães AC, Abreu-Villaça Y, Ribeiro-Carvalho A.   +8 more
europepmc   +1 more source