Results 311 to 320 of about 1,723,437 (335)

Neurology pioneers in Japan. [PDF]

open access: yesArq Neuropsiquiatr
Teive HAG   +3 more
europepmc   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

open access: yesAdvanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi   +21 more
wiley   +1 more source

TRABALHO E SAÚDE MENTAL DAS(OS) DOCENTES, ANTES E DURANTE A COVID-19

open access: yes, 2023
Reis MCPM   +3 more
europepmc   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

open access: yesAdvanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao   +14 more
wiley   +1 more source

USOS DAS TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO NO ENSINO SUPERIOR DURANTE A PANDEMIA DA COVID-19

open access: yes, 2023
Oliveira JP   +5 more
europepmc   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

open access: yesAdvanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao   +6 more
wiley   +1 more source

Confrontations and wear and tear of academic life: a proposal for an undergraduate course. [PDF]

open access: yesRev Esc Enferm USP
Santoro R   +5 more
europepmc   +1 more source

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